Parked at the Upper Canyonback Trailhead at the east side of the Mulholland Drive route and started around 7:30am on the 4th of July with 2 20oz handheld bottles so I didn't need to stop anywhere. I did a little out and back on the Upper Canyonback trail before hitting Mulholland Drive. It was already getting warm by 8am but the fire road was still pretty busy so I wore a mask when I had to. The route is all run-able on wide fire road until the last mile which goes between road, other pavement and dirt. There are a few intersections without signs so its helpful to check out the route before hand on Strava. Turned around and headed back the way I came to finish the rest of my run.
The route is all exposed so it can get pretty hot. There is water at the San Vicente Mountain Park about 1 mile from the East terminus but nothing obvious close to the west side.