This route encompasses the runnable outer borders of San Francisco. It includes the Golden Gate bridge, because this route would not be complete without it (note that you only have to run over the bridge once). At times this route goes into Daly City on the southern edge of SF, as the straight line border of SF cannot be followed, and follows the most popular routes among the bottom.
Tried this route last weekend and it isn't possible. It takes you to the Navy shipyard, which isn't open and fenced off. Happy to suggest a edit and create a route that is possible.