Cuyahoga National Park is not your typical National park. https://en.wikipedia.org/wiki/Cuyahoga_Valley_National_Park It was a designated a National Recreation Area in 1974 but wasn’t given National Park status until the year 2000. The 50 square mile park is the only national park in Ohio. It has been cobbled together from a patchwork of parcels centered around the famous Cuyahoga River. Locals call it "The Burning River" with pride as it has been cleaned up and last caught fire over 50 years ago.
The diversity of trail types and surroundings are amazing for a national park. At times you will find yourself feeling like you are in someone's suburban backyard. At other times you will feel like you are in the remote wilderness. You pass through the historic town of Peninsula, OH. The route makes use of the historic Erie Canal Towpath https://www.nps.gov/cuva/planyourvisit/ohio-and-erie-canal-towpath-trail.htm and spends a considerable amount of miles following the Buckeye Trail which is marked by signs and blue blazes on trees. https://www.buckeyetrail.org/overview.php There are countless trail and road intersections so a GPS with the route will be your best friend.
The North start/finish is in the Bedford Reservation on the Gorge Parkway about 50 yards from the intersection of Egbert Road at the gate to the park.
The South start/finish is the intersection of the West Bath Road and the the Buckeye/Deer Run trail at the bottom of the massive staircase at the edge of O’Neil Woods.