Raphael Kinney submitted this 58km route, covering the main part of Yonge Street between Lake Ontario and Lake Simcoe.  Another section (not continuous) connects Bradford with Barrie.  One of the challenges of an urban street run like this is dealing with traffic & the many street crossings.

The 100-mile Two Moors Way links to the Erme-Plym Trail to create a 117-mile Coast-to-Coast trail route (different from the Devon Coast-to-Coast Cycle Route).  This route has been used for the Devon Coast-to-Coast Ultra Marathon, and to now the fastest times we know of were in the race.  A video from the 2018 race is here:  https://www.youtube.co

https://www.hikespeak.com/los-angeles/verdugo-mountains/